Development of an ESI-UPLC-MS/MS method for determination of baicalin in rat plasma and its applicat

来源 :2015年第一届药代动力学朝阳论坛 | 被引量 : 0次 | 上传用户：Nuangfeng0915

【摘要】

：

　　A sensitive, rapid and selective ultra liquid chromatography-tandem mass spectrometry (UPLC-MS-MS) method was developed and validated for the determination

【作者】

：

CHENFu-xin[1]MAXiao-xian[1]BAIXiao-huan[2]GONGPin[2]

【机构】

：

School of Chemistry and Chemical Engineering, Xi'an University of Science and Technology, Xi'an 71

【出处】

：

2015年第一届药代动力学朝阳论坛

【发表日期】

：

2015年期

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　　A sensitive, rapid and selective ultra liquid chromatography-tandem mass spectrometry (UPLC-MS-MS) method was developed and validated for the determination of baicalin in rat plasma.The oral administration of baicalin tablet was simulated the way of normal delivery;Baicalin tablet were crushed and added to rat chow, final dosage is 200 mg/kg.May be due to the influence of the dosage form, the pharmacokinetic characteristics of baicalin in rats in vivo is significantly different from intragastric administration (ig).

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