【摘 要】
：
Huangqin Tang (HQT) is a well-known traditional Chinese medicine formula, containing Radix Scutellariae, Radix Paeoniae Alba, Radix et Rhizoma Glycyrrhizae
【机 构】
：
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, Chin
【出 处】
：
2015年第一届药代动力学朝阳论坛
论文部分内容阅读
Huangqin Tang (HQT) is a well-known traditional Chinese medicine formula, containing Radix Scutellariae, Radix Paeoniae Alba, Radix et Rhizoma Glycyrrhizae and Jujubae Fructus.The pharmacokinetic (PK) properties of HQT were investigated in trinitrobenzene sulfonic acid and ethanol-induced ulcerative colitis rats.Plasma samples were collected at different time after single and multiple oral administration of HQT at 20 g/kg.The concentrations of paeoniflorin, baicalin, wogonoside, baicalein, wogonin, oroxylin A, glycyrrhizic acid and glycyrrhetinic acid were quantified by a validated LC-MS method.The concentration-time data were then calculated by non-compartmental pharmacokinetic methods using WinNonlin software.
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