【摘 要】
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Purpose: In order to realize pathological changes of the urethral fibrous-muscular system related stress urinary incontinence (SUI), the structural components and the role of TGF-β1/Smad pathway in th
【机 构】
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苏州大学附属第一医院,215006
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Purpose: In order to realize pathological changes of the urethral fibrous-muscular system related stress urinary incontinence (SUI), the structural components and the role of TGF-β1/Smad pathway in the urethra by parturitioninduced SUI was investigated.Materials and Methods: Forty 8-week-old Sprague-Dawley female rats at gestational day 16 were used and immediately after delivery, the rats were underwent vaginal balloon dilation for 4 hours.Results: Four weeks after ovariectomy, SUI model were developed in 17 of 20 experimental rats(85％).Extracellular matrix (ECM) was significantly increased in the urethras of SUI rats compare to normal controls.However, the muscle was significantly decreased compare to controls.
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