【摘 要】
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Background: The ability of the innate immune system to recognize and eliminate invading microbial pathogens has been largely attributed to Toll-like receptors (TLRs) and TLR-triggered immune response.
【机 构】
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National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical Uni
【出 处】
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中国免疫学会第九届全国免疫学学术大会
论文部分内容阅读
Background: The ability of the innate immune system to recognize and eliminate invading microbial pathogens has been largely attributed to Toll-like receptors (TLRs) and TLR-triggered immune response.Although many factors mediate the transduction of TLR signals, the molecular mechanisms involved in the full activation of TLR-triggered innate immunity remain to be fully elucidated.Dendritic cell-derived BTB/POZ zinc finger (DPZF) also named as HOF and ZNF288, belongs to BTB/POZ (broad complex tramtrack bric-a-brac/poxvirus and zinc finger) zinc finger family.DPZF was found to participate in neurogenesis and function as a key transcription repressor of alpha-fetoprotein gene in liver.However,the roles of DPZF in immune system remain unknown.
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