【摘 要】
：
Tripterygium wilfordii Hook.f.has a long history of use in traditional Chinese herbal medicine.It is used for the treatment of arthritis, muscle injury, skin diseases, and other diseases.However, it i
【机 构】
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CAS Key Laboratory of Separation Science for Analytical Chemistry,National Chromatographic R&A Cente
【出 处】
：
第2届大连国际色谱学术报告会、第37届国际高效液相色谱及相关技术会议、第18届全国色谱学术报告会
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Tripterygium wilfordii Hook.f.has a long history of use in traditional Chinese herbal medicine.It is used for the treatment of arthritis, muscle injury, skin diseases, and other diseases.However, it is thought to be toxic or even fatal if taken to excess.Here, a metabolomics-based toxicology approach was used to elucidate the toxicity in SD female rats induced by tripterygiumon.Overnight 12 h urine samples were collected from rats exposed to three different doses and healthy controls at predose and at the 3rd, 5th, 9th, 14th, 19th and 26th day postdose.Urinary metabolic profiling was analyzed by principal component analysis (PCA) to find the differential metabolites and altered biological pathways which are in response of herbal toxin.The results showed that tripterygiumon caused a dose-dependent and time-dependent toxic and it perturbed metabolic regulatory network to disorder amino acid, purine and choline metabolism pathways.Metabolomics can be a systems approach to provide comprehensive information of drug induced toxicity.With metabolomics, the systemic toxic effects can be detected at an earlier stage compared to the histopathological assessment.
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