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Acute graft rejection is a major post-transplant complications of renal transplantation, the success of renal transplantation is closely associated with the ability to control rejection.Therefore, early detection and accurate diagnosis are critical in the management of patients receiving renal transplantation.Metabonomics is the identification and measurement of metabolic profile dynamics of living systems to toxin or drug, environmental changes and diseases.As a powerful analytical platform, the application of metabonomics has increased in therapy and novel potential biomarker discovery.