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Acellular biomaterials prepared from the extracellular matrix of mammalian tissues are increasingly being used in abdominal wall reconstruction but still have certain shortcomings.The present study describes a decellularization protocol to generate porcine-derived decellularized muscular matrix (DMM), a scaffold in which cellular components are effectively removed, retains an intact 3-D architecture as well as biochemical components and mechanical properties.When implanted in a defective rat abdominal wall, the DMM induced tissue remodeling and supported the reconstruction of functional skeletal muscle tissue as compared to porcine-derived acellular dermal matrix.These results show that DMM can serve as a clinically useful material for abdominal wall defect and hernia repair.