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Background According to analyzing the position of the left ventricular lead, assess its impact on the outcome of cardiac resynchronization therapy (CRT).Methods Between March 2001 and January 2012, 158 patients with NYHA function class Ⅲ-Ⅳ and left ventricular ejection fraction (LVEF) ≤35％ (112 men; age (59.02±12.48) years, 112 case were non-ischemic cardiomyopathy, 46 cases were ischemic cardiomyopathy) underwent CRT at the Bethune international Peace hospital and the General hospital of Shenyang military region were enrolled in this study.The distribution of the LV lead location along the long axis was as follows: Group Ⅰ: basal segments (n=28), Group Ⅱ: midventricular segments (n90) and Group Ⅲ: apical segments (n=40).Clinical and echocardiographic assessments were performed at baseline and at 6-months after CRT.