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Physical activity is a peculiar component of rehabilitative therapies in functional recovery after traumatic injuries of nervous system.This talk is devoted to the comprehension of which treadmill running could be beneficial to enhance functional recovery after peripheral nerve injury.We analyzed the effects of different treadmill running protocols on the functional recovery after chronic constriction injury of the sciatic nerve in mice.We found that a treadmill protocol of short-lasting running reduces the neuropathy-induced mechanical allodynia and normalizes the weight bearing and the sciatic static index of the injured hindpaw.