Facile Construction of Pyrrolo[1,2-b]isoquinolin-10(5H)-ones via a Redox-amination-aromatization-Fri

• 作 者: 武善超 盛春泉 张万年
• 机 构: 第二军医大学药学院
• 出 处: 2016年长三角药物化学研讨会
• 发表日期: 2016年11期
• 关键词: Pyrrolo[1 2-b]isoquinolin-10(5H)-ones Cascade Reaction Topoisomerase Inhibitors

　　Pyrrolo[1,2-b]isoquinolone are important scaffolds featured in a number of natural products,such as the lycorine class of Amaryllidaceae alkaloids and the phenanthroindolizidine alkaloids (Figure 1),and exhibit appealing antitumor and antiviral properties.