【摘 要】
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Background This study was designed to observe the predictive effects of anisodamine on myocardial perfusion in patients with ST-segment elevation myocardial infarction (STEMI) undergoing early PCI fol
【机 构】
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Second Hospital of Hebei Medical University
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Background This study was designed to observe the predictive effects of anisodamine on myocardial perfusion in patients with ST-segment elevation myocardial infarction (STEMI) undergoing early PCI following thrombolysis.Methods This study was prospectively observed the hemodynamic effects of anisodemine in STEMI patients undergoing early PCI following thrombolysis.From March 2010 to December 2010, concecutive STEMI patients within12 hours after thrombolysis were enrolled.All eligible patients were randomly assigned to anisodamine group (ANI) and control group (CON).Patients in ANI group received intracoronary bolus injection of anisodamine (2000 μg, 10 ml)over 2 minutes according to the heart rate and blood pressure, and the same vulome of 0.9％ sodium chloride in the CON group.The other medications and laboratory examinations were the same as phase 1.The primary end point was the level of TMPG after PCI, and the second end points were including the hemodymanic parameters, STR, peak level of CK-MB, TIMI flow grade and major adverse cardiac events after PCI.
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