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4-Pyridone derivatives were identified as potent inhibitors of FabI,the enoyl-acyl carrier protein reductase inEscherichia coli and Staphylococcus aureus and to possess moderate reproducible activity against murine P-388leukemia.1-4 We developed an efficient and convenient method for poly-substituted 4-pyridones synthesis veryrecently.Catalized by Na2S2O8,a series of poly-substituted 4-pyridones was synthesized via dimerization ofacetoacetamides (Fig.1).During this transformation,a novel 1,3-acetoacetyl migration would be contained.Theuse of N-alkyl-substituted acetoacetamides for the transformation remains a challenging task.Further studies toclearly understand the reaction mechanism is ongoing in our laboratory.