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Pesticides are extensively used around the world and pesticide toxicity has become a serious threat to human health and eco-environment.Metabonomic approach has been applied in many aspects of pesticide toxicology research such as eco-environmental toxicity studies, biomarker identification, and mechanism of toxicity studies.In order to better understand the actions of multiple pesticides, which are co-existed in the environment and agricultural and food products, applications of metabonomics have been carried out with animal models.