An Efficient Process for the Synthesis of Perfluoroalkylated Benzazepines

来源 :中国化学会全国第十二届有机合成化学学术研讨会 | 被引量 : 0次 | 上传用户：mobydick2000

【摘要】

：

　　Benzazepine moiety occurs frequently in both natural and synthetic drugs and is of highly biological interest.The usage of this class of compound is not mer

【作者】

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SunXuechun[1]HanJing[1]ChenJie[1]ZhangHui[1]CaoWeiguo[2]

【机构】

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Department of Chemistry,Shanghai University,Shanghai 200444,China

【出处】

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中国化学会全国第十二届有机合成化学学术研讨会

【发表日期】

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2015年期

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　　Benzazepine moiety occurs frequently in both natural and synthetic drugs and is of highly biological interest.The usage of this class of compound is not merely confined to the management of stress related conditions and for their use as antibacterial agents1.Besides,the quinoxaline core is present in many drugs with antitumor,anticancer,antiamoebic2 and organic semiconductors3.Because of important applications of benzazepine and quinoxaline compounds in both medicinal and industrial fields,we propose an efficient protocol for the synthesis of perfluoroalkyl compounds 3 consisted of benzazepine and quinoxaline structure with 3-(2-aminophenyl)quinoxalin-2(1H)-one derivatives 1 and 2-perfluoroalkynoate 2.

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An Efficient Process for the Synthesis of Perfluoroalkylated Benzazepines

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