Copper-catalyzed Oxidative C-H Bond Amination of Hydrazones:Efficient Synthesis of Cinnolines

来源 :中国化学会全国第十二届有机合成化学学术研讨会 | 被引量 : 0次 | 上传用户：zhlkf99

【摘要】

：

　　Cinnolines,the privileged structure in molecular skeletons,have a broad range of biological and pharmacological activities,therefore,it has attracted increa

【作者】

：

TianZhuang;GaoMingchun;TanQitao;XuBin;

【机构】

：

Department of Chemistry,Shanghai University,Shanghai 200444,China

【出处】

：

中国化学会全国第十二届有机合成化学学术研讨会

【发表日期】

：

2015年期

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　　Cinnolines,the privileged structure in molecular skeletons,have a broad range of biological and pharmacological activities,therefore,it has attracted increasing attention to the development of its preparation.On the other hand,phosphoryl group has proved to be a good leaving group for our previous synthesis of indazoles and isoquinolines.In the context of our program aiming at efficient construction of heterocycles through tandem reaction strategy,we have developed a copper-catalyzed intramolecular aerobic dehydrogenative amination reaction,whereby a sequential cleavage of one N-P bond and formation of one C-N bond is described from easily prepared phosphorylhydrazones to give substituted cinnolines.

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Copper-catalyzed Oxidative C-H Bond Amination of Hydrazones:Efficient Synthesis of Cinnolines

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