The evidence for bony fish survived from a lethal bacterial challenge A life vest depends on MHC Ⅱ g

• 作 者: Yinan Jiang Jia Cai Nan Li Nianzhi Zhang Ruili Guan Jianmin Chen Zhaohe Wu Yishan Lu Jichang Jian Chun Xia
• 机 构: DepartmentofMicrobiologyandImmunology,CollegeofVeterinaryMedicine,ChinaAgriculturalUniversity,Beijin
• 出 处: 中国水产学会鱼病学专业委员会2011年学术讨论会
• 发表日期: 2011年11期

　　Little is known about the mechanistic explanation of the immune system that allow a bony fish to survive when challenged by a fatal pathogen.Here,10,510 ESTs from a fatal Vibrio alginolyticus-challenged orange-spotted grouper (Osg) have been sequenced,and 141 genes were identified as relating to host defence.Osg that survived pathogen challenge showed upregulated gene expression of IL-1,IL-6,and IL-8,revealing that an inflammatory response had played a vital role in host defence.