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Introduction Imaging is an essential tool to facilitate clinical diagnosis in ophthalmology.Currently most of the medical images are analyzed by human graders,which is very subjective.In this paper,computer aided diagnosis of medical images is investigated in the application of ophthalmology.Automatic processing of slitlamp image for the grading of nuclear cataract,automatic opacity detection in retro-illumination images for the diagnosis of cortical cataract and PSC cataract are described.