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  5. Antinociceptive effects of oxymatrine from Sophora flavescens, through regulation of NR2B-containing

Antinociceptive effects of oxymatrine from Sophora flavescens, through regulation of NR2B-containing

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：pooh__5210
【摘 要】
：
Aim: In this study we investigated anti-nociceptive effects of oxymatrine through regulation of NR2B-containing NMDA receptor-ERK/CREB signaling in a chronicneuropathic pain model induced by chronic c
【作 者】
：
Jian-qiang YU Ru ZHOU Xiao-liang HE Tao SUN Hai-yan WANG Yu-xiang LI Ling-lu DUN Ya-qiong XU Shao-ju JIN Juan DU Lin MA Juan LI 
【机 构】
：
Department of Pharmacology, Ningxia Medical University, Yinchuan, China
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
oxymatrine from Sophoraflavescens NR2B p-ERK p-CREB neuropathic pain 
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Aim: In this study we investigated anti-nociceptive effects of oxymatrine through regulation of NR2B-containing NMDA receptor-ERK/CREB signaling in a chronicneuropathic pain model induced by chronic constrictive injury (CCI) of the sciatic nerve.Methods: The von Frey and plantar tests were performed to assess the degas of mechanical and thermal changes, respectively.Immunohistochemistry assay was used to evaluate the expressions of NR2B.Western blotting assay were used to evaluate the expressions of NR2B, tERK, p-ERK, tCREB, and p-CREB.
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