电化学法评价氯酚类化合物对V79细胞的致突性

来源 :2015毒性测试替代方法与转化毒理学(国际)学术研讨会 | 被引量 : 0次 | 上传用户：mywindjs

【摘要】

：

目的环境化学诱变物数量巨大、种类繁多,人类长期接触可导致动脉硬化、衰老、肿瘤、畸形、不孕等严重后果.因而对环境中诱变物进行致突性检测具有重要意义.然而目前,现有的基因突变检测方法均存在手段繁复,周期长,费用高、误差大等问题.另外,有些试验需要荧光和放射性标记,会对试验人员健康造成伤害.因此,迫切需要发展能够无标记、快速、原位、实时检测基因突变的试验新方法.

【作者】

：

焦宇李光植秦宏伟崔继文毕胜武冬梅

【机构】

：

佳木斯大学药学院,黑龙江佳木斯154007 渤海大学化学化工学院,辽宁锦州121000

【出处】

：

2015毒性测试替代方法与转化毒理学(国际)学术研讨会

【发表日期】

：

2015年5期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

纳米二氧化硅对秀丽隐杆线虫发育繁殖的影响

目的工程化纳米二氧化硅在人们的生产、生活领域得到日益广泛的应用,天然纳米级二氧化硅也是大气复合污染中PM2.5细颗粒物的无机组分之一,但其安全性及健康危害效应尚不明确.根据美国EPA(2009)提出的纳米材料研究策略(EPA 620/K-09/011),本研究采用替代试验方法,以野生型秀丽隐杆线虫N2为测试模型,观察60nm粒径的纳米二氧化硅(以下简称为纳米SiO2)染毒后在线虫体内的吸收分布和

会议

An Integrative Approach for the Prediction of Acute Oral Toxicity: Past and Future

The model presented assesses results of mechanism-based in vitro assays and relevant physical-chemical properties to predict an LD50 value, the standard measurement of acute oral toxicity.

会议

The effects of Perfluorooctane Sulfonate on pluripotency and differentiation factors in mouse embryo

Mouse embryonic stem cells (mESCs) and embryoid bodies (mEBs) are ideal models for developmental toxicity testing of environmental contaminants in vitro.Perfluorooctane sulfonate (PFOS) poses potentia

会议

Cytoskeletons of two reproductive germ cell lines response differently to titanium dioxide nanoparti

Titanium dioxide nanoparticles (TiO 2 NPs) have been widely used for many years.Their toxic effects on the male reproductive system had been reported, but theunderlying mechanisms were still not clear

会议

Titanium dioxide nanoparticlesmale germ cellmicrotubule dynamicmicrofilament

Cigarette smoke and age-related macular degeneration

Age-related macular degeneration (AMD) is associated with many factors, such as aging,family history, smoking, hypertension, hypercholesterolemia and so on.Due to the rapid increase in the age of the

会议

A “female” mouse embryonic stem cell test: a supplementary tool for embryotoxicity prediction

The embryonic stem cell test (EST) has recently been utilized as an alternative test for developmental toxicity despite its numerous improvements across a wide range of species, many issues still rema

会议

CdTe quantum dots induce neurotoxicity modulated by the neurotransmissions of glutamate, serotonin a

Quantum dots (QDs), considered as altematives of conventional fluorescent dyes, are an increasingly used class of nanoparticles in biomedical imagery and target drug delivery.Owning to their unique ph

会议

CdTe quantum dotCaenorhabditis elegansneurotransmissionnanotoxicologyneuroto

基于卡培他滨引起手足综合症的机制研究

目的手足综合症是由药物引起的手掌-足底感觉迟钝及肢端红斑,也称之为掌跖感觉丧失性红斑,是一种严重皮肤不良反应事件,主要发生在受压区域.传统化疗药卡培他滨是新一代口服嘧啶类药物,主要用于治疗晚期乳腺癌及结直肠癌,药效显著,且病人耐受性良好,然而其主要不良反应手足综合症的发生率可高达60％,严重影响了病人的生活质量,并极大的限制了卡培他滨的临床应用价值.深入研究卡培他滨引起手足综合症的分子机制和干预

会议

The Use of Read-across and Structure Activity Relationships for the Safety Assessment of Ingredients

In the European Union animal testing has been eliminated for cosmetic ingredients while the US or other countries may still request data from animal studies.The use of read-across and predictive toxic

会议

Bayesian Integrated Testing to assess the Skin Sensitization Potential of Chemicals

Skin sensitization is a key toxicological endpoint for cosmetic ingredients, with a ban for animal testing in Europe.Alternative tests have been developed some of which are already accepted by OECD as

会议

电化学法评价氯酚类化合物对V79细胞的致突性

其他学术论文