【摘 要】
：
Skin sensitization is a key toxicological endpoint for cosmetic ingredients, with a ban for animal testing in Europe.Alternative tests have been developed some of which are already accepted by OECD as
【机 构】
：
Procter & Gamble Technology, Shunyi District, Beijing, 101312, P.R.China
【出 处】
：
2015毒性测试替代方法与转化毒理学(国际)学术研讨会
论文部分内容阅读
Skin sensitization is a key toxicological endpoint for cosmetic ingredients, with a ban for animal testing in Europe.Alternative tests have been developed some of which are already accepted by OECD as new sensitization testing guidelines.
其他文献
Microcystins (MCs) are a group of widely characterized cyclic heptapeptides able to induce a series of liver injury, including acute liver failure and primary liver cancer.Although the dualistic effec
目的 工程化纳米二氧化硅在人们的生产、生活领域得到日益广泛的应用,天然纳米级二氧化硅也是大气复合污染中PM2.5细颗粒物的无机组分之一,但其安全性及健康危害效应尚不明确.根据美国EPA(2009)提出的纳米材料研究策略(EPA 620/K-09/011),本研究采用替代试验方法,以野生型秀丽隐杆线虫N2为测试模型,观察60nm粒径的纳米二氧化硅(以下简称为纳米SiO2)染毒后在线虫体内的吸收分布和
The model presented assesses results of mechanism-based in vitro assays and relevant physical-chemical properties to predict an LD50 value, the standard measurement of acute oral toxicity.
Mouse embryonic stem cells (mESCs) and embryoid bodies (mEBs) are ideal models for developmental toxicity testing of environmental contaminants in vitro.Perfluorooctane sulfonate (PFOS) poses potentia
Titanium dioxide nanoparticles (TiO 2 NPs) have been widely used for many years.Their toxic effects on the male reproductive system had been reported, but theunderlying mechanisms were still not clear
Age-related macular degeneration (AMD) is associated with many factors, such as aging,family history, smoking, hypertension, hypercholesterolemia and so on.Due to the rapid increase in the age of the
The embryonic stem cell test (EST) has recently been utilized as an alternative test for developmental toxicity despite its numerous improvements across a wide range of species, many issues still rema
Quantum dots (QDs), considered as altematives of conventional fluorescent dyes, are an increasingly used class of nanoparticles in biomedical imagery and target drug delivery.Owning to their unique ph
目的 手足综合症是由药物引起的手掌-足底感觉迟钝及肢端红斑,也称之为掌跖感觉丧失性红斑,是一种严重皮肤不良反应事件,主要发生在受压区域.传统化疗药卡培他滨是新一代口服嘧啶类药物,主要用于治疗晚期乳腺癌及结直肠癌,药效显著,且病人耐受性良好,然而其主要不良反应手足综合症的发生率可高达60％,严重影响了病人的生活质量,并极大的限制了卡培他滨的临床应用价值.深入研究卡培他滨引起手足综合症的分子机制和干预
In the European Union animal testing has been eliminated for cosmetic ingredients while the US or other countries may still request data from animal studies.The use of read-across and predictive toxic