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Multiple model imaging is often employed to complement each other for obtaining more overall information in disease diagnosis.However,the multiple model imaging reagent based on ultrasmall nanoparticles which could be fast cleared still are rarely reported.Hence,we developed the optical/CT(computed tomography)/MR(magnetic resonance)triplemodal probe using biomineralization method with BSA as a templet.In this research,the optimized synthesis conditions,the chemical and physical properties of the as-prepared nanoparticles was investigated,the biocompatibility and tissue distributions of the nanoparticles were also investigated.