The mechanism of Na(+)K(+) selectivity in Mammalian voltage-gated sodium channels based on molecular

• 作 者: Mengdie Xia Huihui Liu Yang Li Nieng Yan Haipeng Gong
• 机 构: MOEKeyLaboratoryofBioinformatics,SchoolofLifeSciences,SchoolofMedicine,TsinghuaUniversity,Beijing,Ch
• 出 处: 第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
• 发表日期: 2014年10期
• 关键词: Voltage-gated sodium channels selectivity MD simulations

　　Background: Voltage-gated sodium (Nav) channels and their Na+/K+ selectivity are of great importance in the mammalian neuronal signaling.According to mutational analysis, the Na+/K+ selectivity in mammalian Nav channels is mainly determined by the Lys and Asp/Glu residues located at the constriction site within the selectivity filter.