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Objective:To investigate the Th 17 cell expression in peripheral blood of children with systemic lupus erythematosus (SLE) and discuss the role of Th17 cells and the cytokines in the pathogenesis of SLE.Methods:Twenty-five children with SLE were enrolled and 15 healthy children as control.Flow cytometry (FCM)was employed to detect the expression of Th17 cells in peripheral blood of SLE children (SLE group,n =25),and IL -17,IL-21 levels in plasma were detected by ELISA.