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Background To investigate the value of color Doppler echocardiography (CDE) in occlusion of elderly with atrial septal defect (ASD).Methods In total of 64 cases of elderly ASD, observe the location, size and residual edge using two-dimensional echocardiography (2DE), observe the atrial septal colorful shunt bunch flow signal and the heart valve colorful regurgitation bunch flow signal using color Doppler flow imaging (CDFI) and measure the pulmonary artery pressure using continuous Doppler (CW) before the occlusion.If the patient had atrial fibrillation or multiple ASDs,transesophageal echocardiography (TEE) examination should be used to screen the patients according to the indication of ASD occlusion.During the procedure of occlusion of ASD, 2DE was used to monitor the position of occluder, CDFI was used to monitor residual shunt through the atrial septum and CDE was used to determine the efficacy of occlusion.