【摘 要】
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Background The aim of the study is to assess efficacy and safety of Fondaparinux during thrombolytic therapy in acute ST-elevation myocardial infarction patients.Methods From November 2011 to April 20
【机 构】
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Department of Cardiology,Institute of Cardiovascular Research of People's Liberation Army,Shenyang
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Background The aim of the study is to assess efficacy and safety of Fondaparinux during thrombolytic therapy in acute ST-elevation myocardial infarction patients.Methods From November 2011 to April 2012, patients with acute ST-elevation myocardial infarction and pain to hospital time within 6 hours were received thrombolytic therapy by recombinant tissue-type plasminogen activator(rt-PA).Before thrombolytic therapy, patients were randomly assigned to Fondaparinux group (2.5 mg, n=30) or standard heparin group (60 U/kg, maximum 4000 U, n=32).Coronary angiography or PCI were performed at 90 minutes after initiating study drugs.Primary endpoints of the trial were the rate of TIMI grade 3 flows at 90 minutes.Other endpoints included incidence of all-cause mortality at in-hospital, 30 days and 6 months, major bleeding and minor bleeding at in-hospital, 30 days and 6 months.
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