【摘 要】
：
NADPH-Cytochrome p450 oxido-reductase (CPR) plays an important role in the metabolism of a wide range of chemicals and drugs.The purpose of this study was to assess the effect of infertility agents on
【机 构】
：
Institute of Biodiversity and Ecology,Zhengzhou University,Zhengzhou,China
【出 处】
：
The 5th International Conference on Rodent Biology and Manag
论文部分内容阅读
NADPH-Cytochrome p450 oxido-reductase (CPR) plays an important role in the metabolism of a wide range of chemicals and drugs.The purpose of this study was to assess the effect of infertility agents on the expression of CPR in plateau pikas (Ochotona curzoniae) .Food baits (oats,fodder or carrot) containing either quinestrol (E) (10 mg/kg) ,levonorgestrel (P) (10 mg/kg) ,EP-1 (mixture,10 mg/kg) or water (control group) were presented to 4 groups of 10 animals for 28 days.Kidney tissues were collected from the animals at 30 days after the start of baiting.A CPR genomic fragment of 2 038 bp of O.curzoniae was amplified and sequenced (accession No.1021728) .Selective pressure analysis identified the following sites to be under positive selection: 21A,79G,127S,160A,207S,239A,418L,541T,632Q,673S,and 727E.Two-way ANOVA showed that quinestrol did not affected the expression of CPR significantly (F1,29 = 2.695,P = 0.111) ,levonorgestrel affected the expression of CPR significantly (F1,29 = 26.967,P <0.001) ,and there was no significant interaction between levonogestrel and quinestrol (F1,29 = 0.137,P = 0.714) .Our study has shown that in plateau pikas,levonorgestrel significantly depresses the expression of CPR by 43.7% (P<0.01) when compared with the control group.
其他文献
At some period of prehistory Black Rats moved from their region of ancestry in India to colonize new territory in the Middle East and Europe,in the process presumably having great impacts on human liv
Recent surveys of genetic diversity among Black Rats (Rattus rattus Complex) suggest a complex evolutionary history involving ancient allopatric divergence of 4 or more regional populations in South t
Rodents are important host animals for many zoonoses that threaten public health worldwide.Gaining accurate taxonomic information on host animals is important for surveillance and epidemiological inve
Small mammals of genus Mastomys are important reservoir hosts of many diseases affecting humans.Knowledge about taxonomic status and distribution range of members of the genus Mastomys in southern Afr
Taxonomy of striped hamsters (Cricetulus barabensis group) is controversial.In particular,taxonomic treatment of the three closely-related chromosomal races ("barabensis" – 2n=20,pseudogriseus – 2n=24
Comparative analysis of genetic variation and phylogenetic relationships can aid the understanding of evolutionary history,correct taxonomic status of species,and establish conservation units.Crocidur
Taxonomic statuses of three subterranean rodents,Lasiopodomys mandarinus,Myospalax psilurus and Myospalax baileyi are still in dispute.To clarify their status the complete mitochondrial genomes of the
The genus Rattus is of central interest to many different fields of biological and medical science but there is significant uncertainty over its evolutionary history and taxonomic content.We explore t
Quinestrol is an effective sterilant of rodents,but we have little knowledge about its effect on social behavior.In this study,we investigated responses in terms of social behavior in male Brandts vol
The industrial chemical,4 vinylcylcohexene diepoxide (VCD) induces depletion of primordial follicles in the ovaries of laboratory mice after intraperitoneal treatment and leads to infertility.This stu