Background and Aims: The mechanism of pain in chronic pancreatitis(CP)is poorly understood and its treatment remains difficult,in large part due to our lack of knowledge about the neurobiological mech
Bis(propyl)-cognitin (B3C),derived from tacrine linking with three methylene (-CH2-) groups,is a multi-target dimmer.During the past several years,it has been reported as a promising therapeutic drug
Objective To investigated the underlying network mechanisms that low frequency stimulation(LFS)of entorhinal cortex(EC)interferes with the hippocampal epileptogenesis and seizures in rodent.Methods Hi
Transient cerebral ischemia leads to the endoplasmic reticulum(ER)stress.However,the contributions of ER stress to cerebral ischemia are not clear.To address this issue,the ER stress activators tunica
Studies have suggested that thalamus is involved in temporal lobe epilepsy,but the role of thalamus is still unclear.We obtained local filed potentials(LFPs)and single-unit activities from CA1 of hipp
So far,12 genetic mutants of sodium-activated potassium channel (KCNT1,Slack) had been found in severe early-onset epilepsy patient by whole genome sequence.However,how the biophysical property of the
Introduction Language function protection is essential for surgical planning.Usually it was done by presurgical task fMRI.Coello et al.(2013)suggested intraoperative electrocortical stimulation(IES)wi
AIM: We investigated the effect of curcumin on depressive-like behaviors in mice with mononeuropathy,and explored the mechanism(s).METHODES: Chronic constriction injury(CCI)was produced by loosely lig