Drug release mechanisms of chemically cross-linked albumin microparticles: effect of the matrix eros

• 作 者: Danielly L.A.Sitta Marcos R.Guilherme Edvani C.Muniz Artur J.M.Valente Adley F.Rubira
• 机 构: Department of Chemistry,State University of Maringá,Maringá CEP 87020-900,Paraná,Brazil
• 出 处: The Third Symposium on Innovative Polymers for Controlled De
• 发表日期: 2014年6期
• 关键词: albumin drug delivery emulsion erosion microparticles drug release kinetics

　　One of the most promising areas of particles is the research and development of new pharmaceutical formulations,being that the main application is aimed towards the drug delivery.Among the various materials used in the production of nano and microparticles,there has been a considerable interest in the proteins as a starting substance for synthesis of more sophisticated release systems that may preserve the molecular structure of more potent and specific drugs [1].Both bovine serum albumin (BSA) and human serum albumin (HSA) are used in the production of nano/microparticles [1,2] in view of their structural similarity that corresponds to 75 %of the homologous sequence.BSA is more suitable for in vivo tests due to its lower cost.