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Understanding the coordination of gene expression in a cell is fundamental to biological economics.By analyzing the global regulatory relationship between thirty three RNA binding proteins (RBPs) in yeast and their target mRNAs under various conditions,we determined that most of these RBP genes are coregulated with their target genes,but the RBPs tend to dampen variation among their target mRNAs.We further examined a well-studied RBP gene,PUF3,and found that the protein decreases the variation of its target mRNAs by differentially affecting their decay.Our results provide new insights into the functional importance of RBPs in coordinating the expression of their targeted mRNAs.