【摘 要】
：
Autophagy is a homeostatic process whereby autophagosomes deliver cytoplasmic components and damaged organelles to lysosomes forming degradative autolysosom
【机 构】
：
SynapticFunctionSectionNINDS,NIHBethesda,USA
【出 处】
：
The 7th International Symposium on Autophagy 2015(第七届自噬国际研讨会
论文部分内容阅读
Autophagy is a homeostatic process whereby autophagosomes deliver cytoplasmic components and damaged organelles to lysosomes forming degradative autolysosomes.Neurons face special challenges in maintaining proper autophagy-lysosomal function.Because mature acidic lysosomes are predominantly localized in the soma and proximal regions of processes, dynein-driven retrograde transport is critical for delivering late endosomal cargos and autophagosomes from distal regions to the soma.Thus, the maturation of autolysosomes depends upon the tight coordination of late endocytic transport and membrane trafficking.Perturbation of dynein function results in dispersion of late endocytic organelles to the cell periphery, impairs clearance of aggregate-prone proteins attributed to autophagy-lysosomal dysfunction, and induces axonal degeneration.However, the mechanisms coordinating late endocytic transport and autophagy-lysosomal function in neurons remain elusive.
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