Physiological roles of autophagy during development Functional analysis of ubiquitin-like proteins

来源 :The 7th International Symposium on Autophagy 2015(第七届自噬国际研讨会 | 被引量 : 0次 | 上传用户：wangrong2000

【摘要】

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　　The diversity of physiological processes associated to autophagy, such as cellular homeostasis,survival, differentiation, development and immunity led to th

【作者】

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Renaud Legouis Céline Jenzer Christophe Lefebvre Emmanuel Culetto Elena Simionato Céline Largeau Marion Manil-Segalen

【机构】

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InstituteforIntegrativeBiologyoftheCell,CEA,CNRS,UniversitéParisSud,1avenuedelaterrasse,91198GifsurY

【出处】

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The 7th International Symposium on Autophagy 2015(第七届自噬国际研讨会

【发表日期】

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2015年3期

【关键词】

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Atg8/LC3 C.elegans embryo selective autophagy

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　　The diversity of physiological processes associated to autophagy, such as cellular homeostasis,survival, differentiation, development and immunity led to the emergence of several animal models among which the nematode C.elegans.Our group aims to understand the particular roles for selective autophagy during developmental processes.The formation of the autophagosomes requires the recruitment of ubiquitin-like proteins to their membrane.The yeast ubiquitin-like Atg8 is highly conserved but presents several homologs in mammals, split into the LC3 and the GABARAP families.C.elegans only possesses one GABARAP and one LC3 homolog named LGG-1 and LGG-2, respectively.

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