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We report that versatile colorimetric logic gates can be designed based on the molecular interactions between metal ions and amino-acids using gold nanoparticles as the indicator.A logic gate system capable of AND,OR,INHIBIT and AND + OR logic operations is constructed.The principle is by modulating the distance between arginine(lysine)-modified gold nanoparticles via metal ions.A lab-on-chip format for assembly of versatile logic gates has been demonstrated for proof of concept.These logic gates allow a straightforward readout by the naked eye.