Role of P2X7 receptor-mediated IL-18/IL-18R signaling in morphine tolerance: multiple glial-neuronal

来源 :International Conference for Physiological Sciences 2012(201 | 被引量 : 0次 | 上传用户：harryxu200x

【摘要】

：

The glial function in morphine tolerance has been explored, but its mechanisms remain unclear.Our previous study has showed that microglia-expressed P2X7 receptors (P2X7R) contribute to the induction

【作者】

：

Hong Cao Meng-Ling Chen Yu-Xia Chu Long-Zhen Cheng Yu-Qiu Zhang Zhi-Qi Zhao

【机构】

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Institute of Neurobiology,Institutes of Brain Science & State Key Laboratory of Medical Neurobiology

【出处】

：

International Conference for Physiological Sciences 2012(201

【发表日期】

：

2012年8期

【关键词】

：

P2X7 receptor IL-18/IL-18R signaling neuronal-glial interaction morphine toleran

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　　The glial function in morphine tolerance has been explored, but its mechanisms remain unclear.Our previous study has showed that microglia-expressed P2X7 receptors (P2X7R) contribute to the induction of tolerance to morphine analgesia in rats.This study further explored the potential downstream mechanisms of P2X7R underlying morphine tolerance.The results revealed that the blockade of P2X7 receptor by P2X7R antagonist or targeting siRNA reduced tolerance to morphine analgesia in the pain behavioral test and spinal extracellular recordings in vivo and whole-cell recording of the spinal cord slice in vitro.

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Role of P2X7 receptor-mediated IL-18/IL-18R signaling in morphine tolerance: multiple glial-neuronal

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