【摘 要】
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OBJECTIVE: To explore the mechanisms of vascular smooth muscle cell (VSMC) senescence and its effects on vascular calcification.METHODS: Twenty-four young rats and 24 elderly rats were divided into fo
【机 构】
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Department of Geriatrics, Yichang Central People's Hospital, The First Clinic Medical School of Chi
【出 处】
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2015中国老年医学和老年健康产业大会
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OBJECTIVE: To explore the mechanisms of vascular smooth muscle cell (VSMC) senescence and its effects on vascular calcification.METHODS: Twenty-four young rats and 24 elderly rats were divided into four groups: normal young group (NY group), young vascular calcification group (Y-VC group), normal elderly group (NE group) and elderly vascular calcification group (E-VC group).The rats were fed for 3 months.Light microscope was used to observe the aorta structure, and Von Kossa staining was used to test vascular calcification;mRNA and protein in aorta osteopontin (OPN), bone morphogenetic protein-2 (BMP-2), p16 and p21 were detected.Serum CRP and serum IL-6 were detected.
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