Intestinal trefoil factor activates PI3K/Akt signaling pathway to protect gastric mucosal epithelium

• 作 者: Zhaorui Sun Hongmei Liu Shinan Nie
• 机 构: Department of Emergency, Jinling Hospital, Medical School of Nanjing University, Nanjing,210002, PR
• 出 处: 第七次全国中毒与危重症救治学术年会暨第二届宝安急危重症高峰论坛
• 发表日期: 2015年7期
• 关键词: Intestinal trefoil factor mucosal epithelium integrity PI3K/Akt signaling pathwa

　　Intestinal trefoil factor (ITF, also named as trefoil factor 3, TFF3) is a member of the TFF-domain peptide family, which plays an essential role in regulating cell survival, cell migration and maintains mucosal epithelial integrity in gastrointestinal tract.However, the underlying mechanisms and associated molecules remain unclear.The aim of this study was to explore the protective effects of ITF on gastric mucosal epithelium injury and its possible molecular mechanism.In the present study, we show that ITF could promote proliferation and migration of GES-1 cells via a mechanism that involves the PI3K/Akt signaling pathway.Western blot results indicated that ITF induced a dose-and time-dependent increase in Akt signaling pathway.ITF also plays an essential role in restitution of GES-1 cells damage induced by LPS (Lipopolysaccharide).