【摘 要】
：
Objective: To enable imaging at an earlier time after injection, a radiopharmaceutical with higher affinity for bone, larger ratio of bone-to-soft tissue uptake and more rapid disappearance from blood
【机 构】
：
Key Laboratory of Nuclear Medicine,Ministry of Health & Jiangsu Key Laboratory of Molecular Nuclear
【出 处】
：
The 1st Sino-American Conference on Nuclear Medicine(首届中美核医学
论文部分内容阅读
Objective: To enable imaging at an earlier time after injection, a radiopharmaceutical with higher affinity for bone, larger ratio of bone-to-soft tissue uptake and more rapid disappearance from blood is required.The purpose of this study is to optimize the linker chain between the imidazolyl and geminal diphosphonate group in the typical third-generation diphosphonate of zoledronic acid (ZL) to develop a novel SPECT bone imaging agent.Methods: A novel ZL derivative, 1-hydroxy-3-(1H-imidazol-1-yl)propane-1,1-diyldiphosphonic acid (IPrDP), was prepared and labeled with 99mTc successfully in a high labeling yield.Single photon emission computed tomography (SPECT) bone scanning was performed on the rabbit.A series of dynamic and static images were recorded by Philips SKY Light emission computed tomography.Results: The time-activity curves indicating the uptake tendency of 99mTc-IPrDP and 99mTc-ZL in the bone and some soft tissues were collected.It is obvious that the uptake ratios of bone to heart,liver, kidney, muscle and stomach increase continuously with the passage of time for both radioligands.Remarkably, in all the period the uptake ratios of bone to soft tissues for 99mTc-IPrDP are much higher than those of 99mTc-ZL.This further demonstrates that 99mTc-IPrDP has good stability in the bone and rapid clearance from the soft tissues.Excellent images of the rabbit skeleton can be quickly obtained for 99mTc-IPrDP, which was faster than 99mTc-ZL and the clinically widely-used bone-imaging agent 99mTc-MDP.On the other hand, one can see that three radiolabeled complexes are all excreted from the kidney from static images, and 99mTc-IPrDP has highly selective skeletal uptake in the rabbit at different time intervals after administration of intravenous injection.Conclusions: 99mTc-IPrDP possesses excellent imaging characteristics for the application as a novel bone scanning agent.And it is notable that 99mTc-IPrDP and 99mTc-ZL are eliminated faster than the clinically widely-used bone-imaging agent 99mTc-MDP.This may shorten the interval and lessen the burden on patients in terms of the total time of examination and the dose of radiation absorbed.
其他文献
Objective: The aim was to evaluate whether 18F-FLT or 18F-FDG can be used complementaily in predicting the potential of metastasis and recurrence in colorectal cancer (CRC).Methods: Human CRC cell lin
Objective: Studied Semi-automated synthesis methods to link radionuclide 18F to Cyclic arginine-glycine-aspartat (RGD) peptide E[c(RGDyK)]2, and explored bio-distribution after the tumor-bearing mouse
OBjective: Vascular endothelial growth factor receptor-2(KDR)is one of the potential ideal target for molecular imaging and molecular therapy of tumor.HTMYYHHYQHHL (K237) was selected from random pept
Objective: Data about the diagnostic efficiency of the 99mTc-MDP triple-phase bone scintigraphy used in identification of peri-prosthetic infection showed a remarkable variability because of using dif
Objective: To analyse diagnostic efficiency of 18F-fluorodeoxyglucose (FDG)coincidence in detecting malignancy and compared with 99mTc-methylene diphosphonic acid 99mTc-methylene diphosphonate (MDP) b
Objective: Hepatocelluar carcinoma (HCC) has a high recurrence rate even after curative resection.Rising AFP levels often occur even when conventional imaging studies and clinical examination are norm
Objective: How to determine the malignant involvement (MI) in bone marrow with 18F-FDG diffuse uptake showed on PET/CT is difficult.We herein retrospectively analyzed 63 patients to establish a diagno
Objective: In this study we evaluated the correlations between the maximum standardized uptake value (SUVmax) of colorectal carcinoma and expression of glucose transporter-1 (GLUT1) and Ki-67.Methods:
Objective: Its a study of bone metastasis before operation on resection of esophageal carcinoma by the whole body bone scintigraphy with 99 Tc m-MDP.Methods: retrospective review the result of 1187 ca
We report the case of a patient who showed right pulmonary hila lung adenocarcinoma with lymph node metastasis and bone metastasis.The case of mediastinal lung adenocarcinoma was misdiagnosed as lymph