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Purpose: To describe clinical characteristics of Purtscher-like retinopathy in systemic lupus erythematosus patients and to find the role of Purtscher-like retinopathy in systemic lupus erythematosus.Methods:Retrospective review.Results: Eight systemic lupus erythematosus patients with Purtscher-like retinopathy were found in our hospital from 2002 to 2013.The mean age was 22.5 years.Fundus abnormalities include Purtscherflecken, cotton-wool spots, retinal hemorrhages, macular edema, optic disk swelling and a pseudo cherry red spot.Fluorescein angiography abnormalities include areas of capillary non-perfusion corresponding to the retinal whitening, late leakage, peripapillary staining, precapillary occlusion, and slower filling of vessels.Six patients were diagnosed as having neuropsychiatric systemic lupus erythematosus (NPSLE), with seizure the most frequent, followed by headache, mood disorder, cognitive dysfunction, cerebrovascular disease, and myelopathy.CSF abnormalities were found in 3 patients.MRI abnormalities were found in 4 patients.High Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)(>15) were shown in all 8 patients.Antinuclear antibodies could be detected in all 8 patients.Anti ribosomal P antibodies were shown to be significantly elevated in 4 patients and anticadiolipin antibody could be found in 3 juvenile patients.Low complements were found in 5 patients.During the follow-up period, hemorrhages and whitish lesions in most eyes disappeared and 67% of the eyes had optic atrophy after 6 months.The eyes with pseudo-cherry red spot and total optic atrophy had the worst visual acuity prognosis.Conclusion:Purtscher-like retinopathy was associated with SLE disease activity, neuropsychiatric systemic lupus erythematosus and had scarcely any association with antiphospholipid antibodies.Although the visual acuity prognosis was unsatisfactory, however, overall survival was good for most patients after prompt treatment.