• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 会议论文
  5. Ad-Vpr上调胶质瘤U251细胞TGFβRⅢ表达和降低其恶性生物学行为

Ad-Vpr上调胶质瘤U251细胞TGFβRⅢ表达和降低其恶性生物学行为

来源 :中华医学会第八次全国中青年检验医学学术会议 | 被引量 : 0次 | 上传用户：fjzxf
【摘 要】
：
大量研究显示1 型人类免疫缺陷病毒 (human immunodeficiency virus type1,HIV-1)编码的病毒辅助蛋白R(viral protein R,Vpr)能够诱导多种肿瘤细胞凋亡和G2 期阻滞,我们的前期研究也证实Vpr 可诱导胶质瘤细胞U251 凋亡和G2 期阻滞,并上调Bax,Caspase-3 和FasL 表达,降低Bcl-2表达,然而Vpr 诱导细胞周期停滞和凋
【作 者】
：
张飚 张述升 冯学泉 徐新女 王金环 
【机 构】
：
天津市环湖医院检验科 天津市第一中心医院 危重病急救医学重点实验室
【出 处】
：
中华医学会第八次全国中青年检验医学学术会议
【发表日期】
：
2014年6期
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
大量研究显示1 型人类免疫缺陷病毒 (human immunodeficiency virus type1,HIV-1)编码的病毒辅助蛋白R(viral protein R,Vpr)能够诱导多种肿瘤细胞凋亡和G2 期阻滞,我们的前期研究也证实Vpr 可诱导胶质瘤细胞U251 凋亡和G2 期阻滞,并上调Bax,Caspase-3 和FasL 表达,降低Bcl-2表达,然而Vpr 诱导细胞周期停滞和凋亡的具体机制仍不明确,本研究应用腺病毒介导Vpr 基因转移,探讨Vpr 对胶质瘤细胞U251 中TGFβRIII 基因表达及恶性生物学行为的影响.
其他文献
Quantum Dots-based Point-of-Care Test for Rapid Quantitative Detection of C-Reactive Protein in Low-
Background Rapid and quantitative detection of proteins in serum is urgently needed for clinical diagnosis,especially for inflammation disease.Herein,we report a novel fluorescent immunosensor for rap
会议
Construction and expression of a recombinant fusion protein containing extracellular domain of human
Objective To construct eukaryotic expression plasmid of recombinant human MED12-Fc using the pIRES2-EGFP-Fc vector.Methods According to the information in GenBank,the sequence of exons 2 to 4 of human
会议
A functional polymorphism affecting the APOA5 gene expression is causatively associated with plasma
Elevated plasma triglyceride (TG) level had been established as an independent risk factor of developing multiple cardiovascular diseases.It is of clinical importance to identify genetic determinants
会议
The NF-KB1 polymorphism (rs4648068) is associated with the cell proliferation and motility in gastri
Background We have demonstrated previously that NF-KB1 single nucleotide polymorphism (SNP) rs4648068 GG homozygote was associated with the increased risk of gastric cancer in Chinese Han population.I
会议
The prognostic value of serum pregnancy-associated plasma protein A, S100 and hypersensitivity C-rea
Aim The concerns regarding the pre-analytical bias caused by medicine treatments have been raised in the diagnostic and prognosis of ischemic stroke recently.The aim of this study was to examine the p
会议
Towards prenatal biomonitoring in Nanjing, China: blood copper, zinc, calcium, magnesium,lead, and c
Background Some element concentrations are altered during pregnancy with the requirements of growing fetus and changes in the motherss physiology.The aim of this study was to evaluate the distribution
会议
First Case of Quambalaria cyanescens Infection in a Patient with Injected Mammaplasty Augmentation i
Quambalaria cyanescens is exceptionally rare as a human pathogen.Implant breast augmentation is one of the most frequently performed surgical procedures,and fungal infection is still considered except
会议
The prevalence and molecular characterization of carbapenem-resistant Klebsiella pneumoniae in a Chi
The aim of this study was to identify the resistance genes and genetic relationship of carbapenemase-producing Klebsiella pneumoniae (CPKP) identified in a tertiary university hospital inChina.Eightee
会议
凝血筛查试验及凝血因子生物学变异研究
背景 临床上凝血筛查实验及凝血因子的检测除用于出凝血疾病的诊断外,对其检测结果的监测还可用于判断疾病进程及监测治疗效果,为了准确评估检测参数的纵向变化,我们通常需要考虑到生物变异(个体内及个体间生物变异).
会议
特发性肺动脉高压时基质金属蛋白酶-2、9及其组织抑制体-1、2的表达意义
目的 探讨特发性肺动脉高压患者基质金属蛋白酶MMP-2 和MMP-9 及其组织抑制体TIMP-1 和TIMP-2的表达变化及意义.方法 采用酶联免疫吸附实验(ELISA)法检测14 例特发性肺动脉高压患者的血清MMP-2 和MMP-9 以及TIMP-1 和TIMP-2 表达水平,同时以20 例健康体检者作为对照,对检测结果进行统计分析.
会议