Mitochondrial dysregulation and protection in cisplatin nephrotoxicity

• 作 者: YuanYang[1]HongLiu[1]FuyouLiu[1]ZhengDong[2]
• 机 构: Department of Nephrology,The Second Xiangya Hospital,Central South University,Changsha,Hunan,China
• 出 处: 中国毒理学会第七次全国毒理学大会暨第八届湖北科技论坛
• 发表日期: 2015年期

　　Nephrotoxicity is a major side effect of cisplatin in chemotherapy.Pathologically, cisplatin nephrotoxicity is characterized by cell injury and death in renal tubules.The research in the past decade has gained significant understanding of the cellular and molecular mechanisms of tubular cell death, revealing a central role of mitochondrial dysregulation.The pathological changes in mitochondria in cisplatin nephrotoxicity are mainly triggered by DNA damage response, pro-apoptotic protein attack, disruption of mitochondrial dynamics, and oxidative stress.As such, inhibitory strategies targeting these cytotoxic events may provide renal protection.Nonetheless, ideal approaches for renoprotection should not only protect kidneys but also enhance the anticancer efficacy of cisplatin in chemotherapy.