【摘 要】
：
甲苯磺酸妥舒沙星(TFLX)是一种新型喹诺酮类广谱抗菌药物，具有优异的抗菌杀菌能力，但存在水溶性差，口服固体制剂溶出度比较低的缺点.文献报道，利用羟丙基-β-环糊精为载体对难溶性药物进行包合，可有效改善药物的溶出度.因此，本研究以羟丙基-β-环糊精为载体，制备了甲苯磺酸妥舒沙星的包合物，利用紫外分光光度计和溶出仪对包合前后的药物溶出进行比较，结果发现：TFLX在pH=1.2的模拟胃液中溶出度由87
【机 构】
：
内蒙古工业大学化工学院,呼和浩特,010051
论文部分内容阅读
甲苯磺酸妥舒沙星(TFLX)是一种新型喹诺酮类广谱抗菌药物，具有优异的抗菌杀菌能力，但存在水溶性差，口服固体制剂溶出度比较低的缺点.文献报道，利用羟丙基-β-环糊精为载体对难溶性药物进行包合，可有效改善药物的溶出度.因此，本研究以羟丙基-β-环糊精为载体，制备了甲苯磺酸妥舒沙星的包合物，利用紫外分光光度计和溶出仪对包合前后的药物溶出进行比较，结果发现：TFLX在pH=1.2的模拟胃液中溶出度由87.8％增加到98.1(见图1)，在pH=6.8的模拟肠液中溶出度由14.0％增加到31.2％(见图2).
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