Renal fibrosis is the final outcome of all progressive kinds of chronic kidney disease.The aim to explore the mechanism and block the progress of renal fibrosis is always an important field in Nephrol
T-2 toxin, a major compound of trichothecenes, inhibits protein synthesis and induces inflammation and cell apoptosis through the activation of MAPK pathway.The JAK/STAT pathway has recently been show
Histone methylation status in different lysine residues has an important role in transcription regulation.The effect of H4K20 monomethylation (H4K20mel) on androgen receptor (AR)-mediated gene transcr
Cell-cycle-dependent temporal transcription of genes is achieved by different mechanisms including a dynamic interaction of activator and repressor proteins with promoters, accumulation (activation) a
The beat-to-beat function of the L-type calcium channel (LTCC) in cardiac myocytes is to provide trigger Ca2+ for excitation-contraction and excitation-transcription coupling.There are two distinct ge
The process in which new vessels grow from an existed vessel is named angiogenesis.Angiogenesis plays an important role in many physiological or pathological processes and is a multi-phases process in