CD147 is highly expressed in tumor tissues and on the membrane of tumor cells.Our previous studies have proved that the interaction of CD147 with integrin can activate the downstream signaling pathway
Directional migration of sperm to oocyte is the prerequisite for successful fertilization.In most animal species, motile sperm are attracted by chemical factors released from oocyte-a process named ch
Renal fibrosis is the final outcome of all progressive kinds of chronic kidney disease.The aim to explore the mechanism and block the progress of renal fibrosis is always an important field in Nephrol
T-2 toxin, a major compound of trichothecenes, inhibits protein synthesis and induces inflammation and cell apoptosis through the activation of MAPK pathway.The JAK/STAT pathway has recently been show
Histone methylation status in different lysine residues has an important role in transcription regulation.The effect of H4K20 monomethylation (H4K20mel) on androgen receptor (AR)-mediated gene transcr
Cell-cycle-dependent temporal transcription of genes is achieved by different mechanisms including a dynamic interaction of activator and repressor proteins with promoters, accumulation (activation) a
The beat-to-beat function of the L-type calcium channel (LTCC) in cardiac myocytes is to provide trigger Ca2+ for excitation-contraction and excitation-transcription coupling.There are two distinct ge