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Aim: To study the sedative and hypnotic effects of GanDanLiangYiTang (GDLYT) and the potential mechanism in mice.Methods: The KM mice were divided into seven groups: the control group, the diazepam group, the BaiLeMian group, and GDLYT 5.2 2.6, 1.3, and 0.65 g/kg group.GDLYT was administered once per day.