Tumor necrosis factor-α regulates the signaling of prostaglandin E2 receptor 4 through the interacti

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：yya_ch

【摘要】

：

【作者】

：

Qing-tong WANG Hua-xun WU Ai-wu ZHOU Yun-fang ZHANG Li-hua LIU Wei WEI Bei HUANG Kang-kang LIU Qiong HUANG Wu-yi SUN Cheng-yi WU Shang-xue YAN Ling-ling ZHANG Jing-yu CHEN

【机构】

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Institute of Clinical Pharmacology,Anhui Medical University,Key Laboratory of Anti-inflammatory and

【出处】

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The 12th Meeting of the Asia Pacific Federation of Pharmacol

【发表日期】

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2013年4期

【关键词】

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tumor necrosis factor-α TNF receptor-associated factor 2 G protein coupled recep

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Aim: In our previous work, we established that upon tumor necrosis factor-α (TNF-α) stimulation, the prostaglandin E2 (PGE2)-PGE2 receptor (EP)-guanine nucleotidebinding protein (G protein)-adenylyl cyclase (AC)-cyclic adenosine monophosphate (cAMP) signal transduction pathway of synoviocytes in collagen-induced arthritis (CIA) rats was unbalanced.

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Tumor necrosis factor-α regulates the signaling of prostaglandin E2 receptor 4 through the interacti

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