Plasma Membrane Proteomics of Tumor Spheres Identify CD166 as a Novel Marker for Cancer Stem-like Ce

• 作 者: MingYan;XihuYang;LizhenWang;DavidClark;HuiZuo;DongxiaYe;WantaoChen;PingZhang;
• 机 构: Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, Shanghai Jiao
• 出 处: 2014全国口腔生物医学学术年会暨“西湖国际”口腔医学高峰论坛
• 发表日期: 2014年期

　　Patients with advanced head and neck squamous cell carcinoma (HNSCC) have a poor prognosis with the currently available therapy, and tumor recurrence is frequently observed.The discovery of specific membraneassociated cancer stem cell (CSC) markers is crucial for the development of novel therapeutic strategies to target these CSCs.To address this issue, we established sphere cultures to enrich CSCs and used them for plasma membrane proteomics to identify specific membrane signatures of the HNSCC spheres.