短链氯化石蜡对HepG2细胞毒性效应的代谢组学评价

来源 :2015毒性测试替代方法与转化毒理学(国际)学术研讨会 | 被引量 : 0次 | 上传用户：aoyun2000

【摘要】

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目的短链氯化石蜡(Short-chain chlorinated paraffins,SCCPs)是链长为10-13个碳原子,氯化程度在30-70％的氯代正构烷烃,于2009年被斯德哥尔摩公约列为持久性有机污染物(POPs)候选物质.已有的动物实验表明, SCCPs具有致癌性,靶器官为肝,肾和甲状腺,但详细深入的毒性效应机制研究仍然缺乏.本文以人体肝癌细胞HepG2为受体细胞,研究了SCCPs暴

【作者】

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耿柠波邢立国张海军

【机构】

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中国科学院大连化学物理研究所,大连116023 沈阳化工研究院有限公司安评中心,沈阳110021

【出处】

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2015毒性测试替代方法与转化毒理学(国际)学术研讨会

【发表日期】

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2015年5期

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