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  5. 内质网应激用于确定常用纳米材料的最低有效毒性剂量

内质网应激用于确定常用纳米材料的最低有效毒性剂量

来源 :2015毒性测试替代方法与转化毒理学(国际)学术研讨会 | 被引量 : 0次 | 上传用户：punkyard
【摘 要】
：
目的 纳米科技的高速发展伴随着纳米材料的安全性日益受到人们的重视.对纳米颗粒(nanoparticles,NPs)的研究揭示出NPs的性质与生物学效应及(或)毒性效应之间有着密切的联系.同时,NPs在工作场所中的释放暴露对人体健康构成潜在的危害.构成毒性效应本质上的原因是外界物质在体内积聚到一定量所造成的,即所谓的最低有效毒性剂量 (lowest effective toxic dose, LET
【作 者】
：
陈瑞 赵琳 陈延东 赵宇亮 常彦忠 陈春英 
【机 构】
：
国家纳米科学中心中国科学院纳米生物效应与安全性重点实验室,北京100190 国家纳米科学中心中国科
【出 处】
：
2015毒性测试替代方法与转化毒理学(国际)学术研讨会
【发表日期】
：
2015年5期
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目的 纳米科技的高速发展伴随着纳米材料的安全性日益受到人们的重视.对纳米颗粒(nanoparticles,NPs)的研究揭示出NPs的性质与生物学效应及(或)毒性效应之间有着密切的联系.同时,NPs在工作场所中的释放暴露对人体健康构成潜在的危害.构成毒性效应本质上的原因是外界物质在体内积聚到一定量所造成的,即所谓的最低有效毒性剂量 (lowest effective toxic dose, LETD).
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