【摘 要】
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Background, Motivation and Objective Accurate discrimination of non-alcoholic steatohepatitis (NASH) from simple fatty liver is a critical issue in current clinical practice because NASH may progress
【机 构】
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Graduate School of Engineering, Chiba University, Chiba, Japan
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Background, Motivation and Objective Accurate discrimination of non-alcoholic steatohepatitis (NASH) from simple fatty liver is a critical issue in current clinical practice because NASH may progress to cirrhosis or even liver cancer. Although the precise mechanisms of NASH progression remain unclear, some reports have shown differences in the content of free fatty acid (FFA) between controls and patients with NASH. Thus, an ultrasound-based diagnostic tool of NASH could be developed by assessing the acoustical properties of FFA. As a first step, this study aimed to evaluate the significance of acoustic impedance measurements using scanning acoustic microscopy (SAM) in order to investigate how FFA content affects the acoustic properties of liver cells at microscopic level.
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