Directing the Fate of Human and Mouse Mesenchymal Stem Cells by Hydroxyl-methyl Mixed Self-assembled

• 作 者: LijingHAO[1]HuiYANG[1]DuCHANG[1]NaruZHAO[1]FuzhaiCUI[2]YingjunWang[1]
• 机 构: School of Materials Science and Engineering,South China University of Technology,Guangzhou,China
• 出 处: The 5th International Congress on Ceramics, ICC5(第五届国际陶瓷大会)
• 发表日期: 2014年期

　　Self-assembled monolayers(SAMs)of alkanethiols on gold have been employed as model substrates to investigate the effects of surface chemistry on cell behavior.However,few studies were dedicated to the substrates with a controlled wettability in studying stem cell fate.Here,mixed hydroxyl(-OH)and methyl(-CH3)terminated SAMs were prepared to form substrates with varying wettability,which were used to study the effects of wettability on the adhesion,proliferation and osteogenic differentiation of mesenchymal stem cells(MSCs)from human and mouse origins.