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Understanding the shape effect of hydroxyapatite(HAp)microparticles on cellular behavior is important for enabling kinds of new biological and biomedical applications.However,its still a challenge to prepare HAp microparticles with different shape but similar physicochemical properties,and then investigate their relationships with cellular behavior.Herein,we developed a novel,facile route to regulate the morphology of HAp microparticles,and investigated the interaction between the particles with bone marrow mesenchymal stem cells(BMSCs).